Advanced Pathophysiology Resources PUB MED Literature

I searched through PUB MED to find some current REVIEW articles that look potentially interesting for this course content. Our understanding of pathophysiology is constantly evolving and these reviews shed light on some of the newest thinking. Of course I don’t have the time to review all of them, but this should help give you a head start with your preps!

Gastrointestinal System

Celiac disease: an overview from pathophysiology to treatment.
Mubarak A, Houwen RH, Wolters VM.
Minerva Pediatr. 2012 Jun;64(3):271-87. Review.
PMID: 22555320 [PubMed – indexed for MEDLINE]

Irritable bowel syndrome: methods, mechanisms, and pathophysiology. Genetic epidemiology and pharmacogenetics in irritable bowel syndrome.
Camilleri M, Katzka DA.
Am J Physiol Gastrointest Liver Physiol. 2012 May 15;302(10):G1075-84. Epub 2012 Mar 8.Review.

Irritable bowel syndrome: methods, mechanisms, and pathophysiology. Neural and neuro-immune mechanisms of visceral hypersensitivity in irritable bowel syndrome.
Feng B, La JH, Schwartz ES, Gebhart GF.
Am J Physiol Gastrointest Liver Physiol. 2012 May 15;302(10):G1085-98. Epub 2012 Mar 8.Review.

The pathophysiology of chronic constipation.
Andrews CN, Storr M.
Can J Gastroenterol. 2011 Oct;25 Suppl B:16B-21B. Review.
PMID: 22114753 [PubMed – indexed for MEDLINE]

Pathophysiology of functional dyspepsia.
Futagami S, Shimpuku M, Yin Y, Shindo T, Kodaka Y, Nagoya H, Nakazawa S, Fujimoto M, Izumi N, Ohishi N, Kawagoe T, Horie A, Iwakiri K, Sakamoto C.
J Nihon Med Sch. 2011;78(5):280-5. Review.

Traditional thoughts on the pathophysiology of irritable bowel syndrome.
Hasler WL.
Gastroenterol Clin North Am. 2011 Mar;40(1):21-43. Review.

IBS in 2010: advances in pathophysiology, diagnosis and treatment.
Ford AC, Talley NJ.
Nat Rev Gastroenterol Hepatol. 2011 Feb;8(2):76-8. Review.

Pathophysiology of gastroesophageal reflux disease.
Lee YY, McColl KE.
Best Pract Res Clin Gastroenterol. 2013 Jun;27(3):339-51. doi: 10.1016/j.bpg.2013.06.002. Review.

NEW!!  Pathophysiology of gastroesophageal reflux disease: new understanding in a new era.
Herregods TV, Bredenoord AJ, Smout AJ.
Neurogastroenterol Motil. 2015 Sep;27(9):1202-13. doi: 10.1111/nmo.12611. Epub 2015 Jun 5. Review.

NEW!!  Recent developments in the pathophysiology of irritable bowel syndrome.
El-Salhy M.
World J Gastroenterol. 2015 Jul 7;21(25):7621-36. doi: 10.3748/wjg.v21.i25.7621. Review.
Free PMC Article

Neurological System

Schizophrenia and the immune system: pathophysiology, prevention, and treatment.
Richard MD, Brahm NC.
Am J Health Syst Pharm. 2012 May 1;69(9):757-66. Review.
PMID: 22517021 [PubMed – indexed for MEDLINE]

Pathophysiology of migraine.
Cutrer FM.
Semin Neurol. 2010 Apr;30(2):120-30. Epub 2010 Mar 29. Review.

NEW!!   Migraine: multiple processes, complex pathophysiology.
Burstein R, Noseda R, Borsook D.
J Neurosci. 2015 Apr 29;35(17):6619-29. doi: 10.1523/JNEUROSCI.0373-15.2015. Review.
Free PMC Article

NEW!!   The pathophysiology of insomnia.
Levenson JC, Kay DB, Buysse DJ.
Chest. 2015 Apr;147(4):1179-92. doi: 10.1378/chest.14-1617. Review.
Free PMC Article

NEW!!   Depression: from psychopathology to pathophysiology.
Belzung C, Willner P, Philippot P.
Curr Opin Neurobiol. 2015 Feb;30:24-30. doi: 10.1016/j.conb.2014.08.013. Epub 2014 Sep 15. Review.

Neural circuits underlying the pathophysiology of mood disorders.
Price JL, Drevets WC.
Trends Cogn Sci. 2012 Jan;16(1):61-71. Epub 2011 Dec 21. Review.

The role of inflammation in the pathophysiology of depression: different treatments and their effects.
Lotrich FE, El-Gabalawy H, Guenther LC, Ware CF.
J Rheumatol Suppl. 2011 Nov;88:48-54. Review.

Links between genetics and pathophysiology in the autism spectrum disorders.
Holt R, Monaco AP.
EMBO Mol Med. 2011 Aug;3(8):438-50. doi: 10.1002/emmm.201100157. Review.

Milestones in research on the pathophysiology of Parkinson’s disease.
Wichmann T, DeLong MR, Guridi J, Obeso JA.
Mov Disord. 2011 May;26(6):1032-41. doi: 10.1002/mds.23695. Review.

Understanding the role of inflammatory-related pathways in the pathophysiology and treatment of psychiatric disorders: evidence from human peripheral studies and CNS studies.
Dean B.
Int J Neuropsychopharmacol. 2011 Aug;14(7):997-1012. Epub 2010 Dec 15. Review.
Tremor: pathophysiology.
Hallett M.
Parkinsonism Relat Disord. 2014 Jan;20 Suppl 1:S118-22. doi: 10.1016/S1353-8020(13)70029-4. Review.

Pathophysiology of migraine.
Pietrobon D, Moskowitz MA.
Annu Rev Physiol. 2013;75:365-91. doi: 10.1146/annurev-physiol-030212-183717. Epub 2012 Nov 26. Review.

Understanding the pathophysiology of itch.
Garibyan L, Rheingold CG, Lerner EA.
Dermatol Ther. 2013 Mar-Apr;26(2):84-91. doi: 10.1111/dth.12025. Review.

Restless legs syndrome: pathophysiology and modern management.
Nagandla K, De S.
Postgrad Med J. 2013 Jul;89(1053):402-10. doi: 10.1136/postgradmedj-2012-131634. Epub 2013 Mar 22. Review.

NEW!!   Pathophysiology of major depressive disorder: mechanisms involved in etiology are not associated with clinical progression.
Verduijn J, Milaneschi Y, Schoevers RA, van Hemert AM, Beekman AT, Penninx BW.
Transl Psychiatry. 2015 Sep 29;5:e649. doi: 10.1038/tp.2015.137.

NEW!!  What Do We Know About the Pathophysiology of Chronic Pain? Implications for Treatment Considerations.
Aronoff GM.
Med Clin North Am. 2016 Jan;100(1):31-42. doi: 10.1016/j.mcna.2015.08.004. Epub 2015 Oct 27. Review.

Endocrine System

Role of vitamin D in the pathophysiology and treatment of type 2 diabetes.
Stivelman E, Retnakaran R.
Curr Diabetes Rev. 2012 Jan;8(1):42-7. Review.
PMID: 22414057 [PubMed – indexed for MEDLINE]

Pathophysiology of the metabolic syndrome: implications for the cardiometabolic risks associated with type 2 diabetes.
Leroith D.
Am J Med Sci. 2012 Jan;343(1):13-6. Review.

Leptin in human physiology and pathophysiology.
Mantzoros CS, Magkos F, Brinkoetter M, Sienkiewicz E, Dardeno TA, Kim SY, Hamnvik OP, Koniaris A.
Am J Physiol Endocrinol Metab. 2011 Oct;301(4):E567-84. Epub 2011 Jul 26. Review.

Type 2 diabetes across generations: from pathophysiology to prevention and management.
Nolan CJ, Damm P, Prentki M.
Lancet. 2011 Jul 9;378(9786):169-81. Epub 2011 Jun 24. Review.
PMID: 21705072 [PubMed – indexed for MEDLINE]

Pathophysiology of prediabetes.
Ferrannini E, Gastaldelli A, Iozzo P.
Med Clin North Am. 2011 Mar;95(2):327-39, vii-viii. Review.

Metabolic syndrome: from the genetics to the pathophysiology.
Sookoian S, Pirola CJ.
Curr Hypertens Rep. 2011 Apr;13(2):149-57. Review.
PMID: 20957457 [PubMed – indexed for MEDLINE]

Pathophysiology of diabetes in elderly people.
Paolisso G.
Acta Biomed. 2010;81 Suppl 1:47-53. Review.

The chronobiology, etiology and pathophysiology of obesity.
Garaulet M, Ordovás JM, Madrid JA.
Int J Obes (Lond). 2010 Dec;34(12):1667-83. Epub 2010 Jun 22. Review.
Pathophysiology of human visceral obesity: an update.
Tchernof A, Després JP.
Physiol Rev. 2013 Jan;93(1):359-404. doi: 10.1152/physrev.00033.2011. Review.

A cyclic pain: the pathophysiology and treatment of menstrual migraine.
Mathew PG, Dun EC, Luo JJ.
Obstet Gynecol Surv. 2013 Feb;68(2):130-40. doi: 10.1097/OGX.0b013e31827f2496. Review.

Dyslipidemia in type 2 diabetes: prevalence, pathophysiology, and management.
Chehade JM, Gladysz M, Mooradian AD.
Drugs. 2013 Mar;73(4):327-39. doi: 10.1007/s40265-013-0023-5. Review.

Pathophysiology of polycystic ovary syndrome: the role of hyperandrogenism.
Catteau-Jonard S, Dewailly D.
Front Horm Res. 2013;40:22-7. doi: 10.1159/000341679. Epub 2012 Oct 18. Review.

Pathophysiology of prediabetes and treatment implications for the prevention of type 2 diabetes mellitus.
Bergman M.
Endocrine. 2013 Jun;43(3):504-13. doi: 10.1007/s12020-012-9830-9. Epub 2012 Nov 7. Review.

Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future.
Kahn SE, Cooper ME, Del Prato S.
Lancet. 2014 Mar 22;383(9922):1068-83. doi: 10.1016/S0140-6736(13)62154-6. Epub 2013 Dec 3. Review.

Cardiovascular System

Cardiovascular metabolic syndrome: mediators involved in the pathophysiology from obesity to coronary heart disease.
Roos CJ, Quax PH, Jukema JW.
Biomark Med. 2012 Feb;6(1):35-52. Review.
PMID: 22296195 [PubMed – indexed for MEDLINE]

Pathophysiology of atherosclerosis: the role of inflammation.
Tousoulis D, Kampoli AM, Papageorgiou N, Androulakis E, Antoniades C, Toutouzas K, Stefanadis C.
Curr Pharm Des. 2011 Dec;17(37):4089-110. Review.

Pathogenesis and pathophysiology of aortic valve stenosis in adults.
Olszowska M.
Pol Arch Med Wewn. 2011 Nov;121(11):409-13. Review. English, Polish.
PMID: 22129836 [PubMed – indexed for MEDLINE] Free Article

Atrial fibrillation pathophysiology: implications for management.
Iwasaki YK, Nishida K, Kato T, Nattel S.
Circulation. 2011 Nov 15;124(20):2264-74. Review.

Atrial fibrillation: pathophysiology and current therapy.
Miyazaki S, Shah AJ, Scherr D, Haïssaguerre M.
Ann Med. 2011;43(6):425-36. doi: 10.3109/07853890.2011.554426. Epub 2011 Mar 2.Review.

Ischaemic heart disease in women: are there sex differences in pathophysiology and risk factors? Position paper from the working group on coronary pathophysiology and microcirculation of the European Society of Cardiology.
Vaccarino V, Badimon L, Corti R, de Wit C, Dorobantu M, Hall A, Koller A, Marzilli M, Pries A, Bugiardini R; Working Group on Coronary Pathophysiology and Microcirculation.
Cardiovasc Res. 2011 Apr 1;90(1):9-17. Epub 2010 Dec 14. Review.
PMID: 21159671 [PubMed – indexed for MEDLINE] Free PMC Article

Pathophysiology of fluid retention in heart failure.
Chaney E, Shaw A.
Contrib Nephrol. 2010;164:46-53. Epub 2010 Apr 20. Review.

Heart failure: pathophysiology and clinical picture.
Palazzuoli A, Nuti R.
Contrib Nephrol. 2010;164:1-10. Epub 2010 Apr 20. Review.

Pathophysiology of anemia in heart failure.
Anand IS.
Heart Fail Clin. 2010 Jul;6(3):279-88. Review.
PMID: 20630402 [PubMed – indexed for MEDLINE]
Pathophysiology and etiology of heart failure.
Johnson FL.
Cardiol Clin. 2014 Feb;32(1):9-19, vii. doi: 10.1016/j.ccl.2013.09.015. Review.

The clinical profile and pathophysiology of atrial fibrillation: relationships among clinical features, epidemiology, and mechanisms.
Andrade J, Khairy P, Dobrev D, Nattel S.
Circ Res. 2014 Apr 25;114(9):1453-68. doi: 10.1161/CIRCRESAHA.114.303211. Review.

NEW!!  Heart Failure: Pathophysiology, Diagnosis, Medical Treatment Guidelines, and Nursing Management.
Rogers C, Bush N.
Nurs Clin North Am. 2015 Dec;50(4):787-99. doi: 10.1016/j.cnur.2015.07.012. Review.

NEW!!  The pathophysiology of pulmonary hypertension in left heart disease.
Breitling S, Ravindran K, Goldenberg NM, Kuebler WM.
Am J Physiol Lung Cell Mol Physiol. 2015 Nov 1;309(9):L924-41. doi: 10.1152/ajplung.00146.2015. Epub 2015 Aug 21. Review.

NEW!!  Pathophysiology of Myocardial Infarction.
Frangogiannis NG.
Compr Physiol. 2015 Sep 20;5(4):1841-75. doi: 10.1002/cphy.c150006. Review.

NEW!!  Pathophysiology and clinical evaluation of acute heart failure.
Mentz RJ, O’Connor CM.
Nat Rev Cardiol. 2016 Jan;13(1):28-35. doi: 10.1038/nrcardio.2015.134. Epub 2015 Sep 15. Review.

NEW!!   Role of inflammation in atrial fibrillation pathophysiology and management.
Harada M, Van Wagoner DR, Nattel S.
Circ J. 2015;79(3):495-502. doi: 10.1253/circj.CJ-15-0138. Epub 2015 Feb 16. Review.
Free PMC Article

NEW!!   Pathophysiology of venous thrombosis.
Myers DD Jr.
Phlebology. 2015 Mar;30(1 Suppl):7-13. doi: 10.1177/0268355515569424.

Respiratory System

Asthma: pathophysiology, diagnosis and management.
Kaufman G.
Nurs Stand. 2011 Oct 5-11;26(5):48-56; quiz 58. Review.

Recent advances in the pathophysiology of asthma.
Murphy DM, O’Byrne PM.
Chest. 2010 Jun;137(6):1417-26. Review.

Current understanding of the pathophysiology of allergic rhinitis.
Rosenwasser LJ.
Immunol Allergy Clin North Am. 2011 Aug;31(3):433-9. Epub 2011 Jun 12. Review.
PMID: 21737035 [PubMed – indexed for MEDLINE]

Recent advances in the pathophysiology of asthma.
Murphy DM, O’Byrne PM.
Chest. 2010 Jun;137(6):1417-26. Review.

Pathophysiology of asthma: what has our current understanding taught us about new therapeutic approaches?
Holgate ST.
J Allergy Clin Immunol. 2011 Sep;128(3):495-505. Epub 2011 Jul 31. Review.

Allergic rhinitis: Pathophysiology.
Broide DH.
Allergy Asthma Proc. 2010 Sep-Oct;31(5):370-4. Review.

What’s new in asthma pathophysiology and immunopathology?
Orihara K, Dil N, Anaparti V, Moqbel R.
Expert Rev Respir Med. 2010 Oct;4(5):605-29. Review.
COPD updates: what’s new in pathophysiology and management?
Noujeim C, Bou-Khalil P.
Expert Rev Respir Med. 2013 Aug;7(4):429-37. doi: 10.1586/17476348.2013.814392. Review.

Pathophysiology, diagnosis, and clinical assessment of asthma in the adult.
Killeen K, Skora E.
Nurs Clin North Am. 2013 Mar;48(1):11-23. doi: 10.1016/j.cnur.2012.11.001. Review

NEW!! Asthma: definitions and pathophysiology.
Mims JW.
Int Forum Allergy Rhinol. 2015 Sep;5 Suppl 1:S2-6. doi: 10.1002/alr.21609. Review.

NEW!!  Dyspnoea: Pathophysiology and a clinical approach.
Coccia CB, Palkowski GH, Schweitzer B, Motsohi T, Ntusi NA.
S Afr Med J. 2016 Jan;106(1):32-6. Review.

NEW!!  Pathophysiology of Pulmonary Hypertension in Chronic Parenchymal Lung Disease.
Singh I, Ma KC, Berlin DA.
Am J Med. 2016 Apr;129(4):366-71. doi: 10.1016/j.amjmed.2015.11.026. Epub 2015 Dec 17. Review.

Musculoskeletal System

Physiology and pathophysiology of nitrosative and oxidative stress in osteoarthritic joint destruction.
Ziskoven C, Jäger M, Kircher J, Patzer T, Bloch W, Brixius K, Krauspe R.
Can J Physiol Pharmacol. 2011 Jul;89(7):455-66. Epub 2011 Jul 27. Review.

Fibromyalgia: from pathophysiology to therapy.
Schmidt-Wilcke T, Clauw DJ.
Nat Rev Rheumatol. 2011 Jul 19;7(9):518-27. doi: 10.1038/nrrheum.2011.98. Review.
PMID: 21769128 [PubMed – indexed for MEDLINE]

Role of proinflammatory cytokines in the pathophysiology of osteoarthritis.
Kapoor M, Martel-Pelletier J, Lajeunesse D, Pelletier JP, Fahmi H.
Nat Rev Rheumatol. 2011 Jan;7(1):33-42. Epub 2010 Nov 30. Review.

A systems approach to bone pathophysiology.
Weiss AJ, Lipshtat A, Mechanick JI.
Ann N Y Acad Sci. 2010 Nov;1211:9-24. doi: 10.1111/j.1749-6632.2010.05816.x. Review.

The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis.
Sellam J, Berenbaum F.
Nat Rev Rheumatol. 2010 Nov;6(11):625-35. Epub 2010 Oct 5. Review.

The pathophysiology of the aging skeleton.
Syed FA, Ng AC.
Curr Osteoporos Rep. 2010 Dec;8(4):235-40. Review.

NEW!!   The Pathophysiology and Treatment of Osteoporosis.
Drake MT, Clarke BL, Lewiecki EM.
Clin Ther. 2015 Aug;37(8):1837-50. doi: 10.1016/j.clinthera.2015.06.006. Epub 2015 Jul 7. Review.

Immune System

Pathophysiology of allergic inflammation.
Barnes PJ.
Immunol Rev. 2011 Jul;242(1):31-50. doi: 10.1111/j.1600-065X.2011.01020.x. Review.
PMID: 21682737 [PubMed – indexed for MEDLINE]

A brief comparison of the pathophysiology of inflammatory versus neuropathic pain.
Xu Q, Yaksh TL.
Curr Opin Anaesthesiol. 2011 Aug;24(4):400-7. Review.
PMID: 21659872 [PubMed – indexed for MEDLINE] Free PMC Article

Stroke and the immune system: from pathophysiology to new therapeutic strategies.
Macrez R, Ali C, Toutirais O, Le Mauff B, Defer G, Dirnagl U, Vivien D.
Lancet Neurol. 2011 May;10(5):471-80. Review.

Pathophysiology of rheumatoid arthritis.
Cooles FA, Isaacs JD.
Curr Opin Rheumatol. 2011 May;23(3):233-40. Review.

Pathophysiology of allergic and nonallergic rhinitis.
Sin B, Togias A.
Pathophysiology of and potential new therapies for allergic rhinitis.
Osguthorpe JD.
Int Forum Allergy Rhinol. 2013 May;3(5):384-92. doi: 10.1002/alr.21120. Epub 2012 Nov 28. Review.

Reproductive System

NEW!!   Premenstrual syndrome: management and pathophysiology.
Imai A, Ichigo S, Matsunami K, Takagi H.
Clin Exp Obstet Gynecol. 2015;42(2):123-8. Review.

NEW!!   Do we understand the pathophysiology of endometrial cancer?
Parker VL, Sanderson P, Raw D, Farag K.
Eur J Gynaecol Oncol. 2015;36(5):595-8.